Comparative effects of drugs for adults with overweight or obesity: systematic review and network meta-analysis
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The authors aimed to evaluate the comparative benefits and harms of various pharmacological treatments for adults with overweight or obesity through a systematic review and network meta-analysis. They found that while several drugs, particularly tirzepatide and CagriSema, led to significant weight loss compared to lifestyle modifications, these benefits were often accompanied by increased risks of adverse events. Additionally, most medications did not meaningfully improve quality of life or show substantial cardiovascular benefits, highlighting the need for careful consideration of trade-offs in clinical decision-making.
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