June 18, 2026 · BMJ (Clinical research ed.) · DOI: 10.1136/bmj-2026-729694

Stereotactic radiotherapy for neovascular age related macular degeneration: year 3 and 4 extended follow up results of a randomised, double masked, sham controlled, device trial (STAR)

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The authors aimed to evaluate the long-term effects of stereotactic radiotherapy (SRT) on patients with neovascular age-related macular degeneration (AMD) beyond the initial two-year results of the STAR trial. They found that while SRT led to a reduction in the number of anti-VEGF injections over four years, it was associated with a significant decline in visual acuity compared to the sham treatment, ultimately questioning the efficacy of SRT for this condition. The study highlights the importance of extended follow-up in clinical trials to provide comprehensive insights into treatment outcomes.

Timothy L Jackson, Riti Desai, Hatem A Wafa, Chan Ning Lee, Yanzhong Wang, Janet L Peacock, Tunde Peto, Usha Chakravarthy, Xuemin Zhu, Helen Dakin, Sarah Wordsworth, Patricia Clinch, Lisa Ramazzotto, James E Neffendorf, Joe M O'Sullivan, Barnaby C Reeves, STAR study group

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