June 23, 2026 · Gastroenterology · DOI: 10.1053/j.gastro.2026.06.006

Proactive Fecal Calprotectin Home Monitoring in Ulcerative Colitis: Results of a Prospective Randomized Control Trial

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This study aimed to determine whether proactive home monitoring of fecal calprotectin (FC) could prevent symptomatic flares in patients with ulcerative colitis in remission. The results showed no significant difference in the risk of symptomatic flares between patients receiving FC monitoring and those receiving standard care, indicating that this approach does not effectively prevent flares. Further research is needed to explore the optimal use of FC monitoring and the potential benefits of early intervention.

Gregory Rosenfeld, Neeraj Narula, Yvette Leung, Waqqas Afif, Astrid-Jane Williams, Vivian Huang, Harminder Singh, Jeffrey D McCurdy, Vipul Jairath, Mindy Lam, Dustin E Loomes, Petros Zezos, Michael Stewart, Christopher Ma, Mark Ropeleski, Maria Ancheta-Schmit, Pedram Tavakoli, Jeffrey N Bone, James D Lewis, Jean-Frederic Colombel, Brian Bressler

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