Epithelial FOXP3 orchestrates O-glycosylated IL-6 secretion to drive pancreatic fibrocarcinogenesis
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The authors investigate the role of the transcription factor FOXP3 in the early stages of pancreatic ductal adenocarcinoma (PDAC) and its contribution to pancreatic fibrosis. They find that epithelial FOXP3 drives the glycosylation and secretion of IL-6, which activates pancreatic stellate cells and promotes a feedback loop that exacerbates fibrosis and neoplasia. This study highlights the potential of targeting the E-FOXP3-GALNT1-IL-6 signaling pathway to intervene in pancreatic fibrosis and cancer development.
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