Urodynamic and Anamnestic Predictors for Individual Dose Adjustment of Intravesical Oxybutynin in Neurogenic Detrusor Overactivity: Results From the UPSIDE Study
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The UPSIDE study aimed to identify urodynamic and anamnestic predictors for achieving a therapeutically satisfactory dose (TSD) of intravesical oxybutynin (IVO) in patients with neurogenic detrusor overactivity (NDO). The study found that older age and reduced estimated glomerular filtration rate (eGFR) were significant predictors for TSD, and IVO treatment led to notable improvements in urodynamic parameters, continence, quality of life, and reduced urinary tract infections, with high adherence and no serious adverse events reported.
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