June 23, 2026 · Neurourology and urodynamics · DOI: 10.1002/nau.70329

Urodynamic and Anamnestic Predictors for Individual Dose Adjustment of Intravesical Oxybutynin in Neurogenic Detrusor Overactivity: Results From the UPSIDE Study

Listen to this summary

The UPSIDE study aimed to identify urodynamic and anamnestic predictors for achieving a therapeutically satisfactory dose (TSD) of intravesical oxybutynin (IVO) in patients with neurogenic detrusor overactivity (NDO). The study found that older age and reduced estimated glomerular filtration rate (eGFR) were significant predictors for TSD, and IVO treatment led to notable improvements in urodynamic parameters, continence, quality of life, and reduced urinary tract infections, with high adherence and no serious adverse events reported.

Arndt Van Ophoven, Severine Banek, Kristin Becker, Markus Heibel, Almut Hirsch, Margot Kieruj, Ines Kurze, Anja Lingnau, Barbara Ludwikowski, Tobias Luithle, Fabian Queissert, Wolfgang Rösch, Oliver Schindler, Regina Stredele, Thomas Michael Karl Völkl, Quentin Leidl, Michael Gedamke

This is one of 33,000+ journals available on OSLR. Try it free for 14 days.

Free 14-day trial. 33,000+ journals. Cancel anytime.

14-day free trial. No commitment.

"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."

Dr. Jennifer Thompson

Dr. Jennifer Thompson

Portland, OR

Stay current without falling behind

33,000+ journals. 3-minute audio summaries. Free for 14 days.

Download on the App StoreGet it on Google Play