Quantitative Serological Detection of NELL1 Autoantibodies in Membranous Nephropathy
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The authors aimed to develop a high-throughput serological assay for the detection of NELL1 autoantibodies in patients with membranous nephropathy (MN), which is currently diagnosed mainly through invasive methods. They created a luciferase immunoprecipitation system (LIPS) that demonstrated high sensitivity and specificity for identifying NELL1 autoantibodies, suggesting its potential as a noninvasive diagnostic tool and for monitoring disease progression. The study highlights the importance of this assay in improving the clinical management of NELL1-associated MN.
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