June 18, 2026 · Kidney international · DOI: 10.1016/j.kint.2026.04.011

A potential role for effector T cells with Fc receptors in kidney transplant antibody-mediated rejection

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The authors investigate the potential involvement of effector T cells with Fc receptors in the mechanism of antibody-mediated rejection in kidney transplants, a significant contributor to transplant failure. They highlight the established role of natural killer cells and propose that these T cells may also interact with donor-specific antibodies, suggesting a more complex pathogenesis of rejection than previously understood.

Patrick T Gauthier, Philip F Halloran

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