June 18, 2026 · Resuscitation · DOI: 10.1016/j.resuscitation.2026.111179

Comparison of Intraosseous Line Placement Location and Rates of Return of Spontaneous Circulation and Survival to Discharge Among Patients with Out-of-Hospital Cardiac Arrest

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The authors aimed to compare the outcomes of return of spontaneous circulation (ROSC), survival to discharge, and neurological status in out-of-hospital cardiac arrest patients based on the location of intraosseous (IO) line placement, specifically humeral versus tibial. Their findings indicate that humeral IO placement is associated with significantly higher rates of ROSC and survival to discharge compared to tibial placement. The study suggests a need for further research to potentially inform protocol changes regarding optimal IO placement in cardiac arrest scenarios.

Andrea Witherell, Amanda Castillo, Emmelyn Samones, Tammy H Phan, Pramil Singh, Christopher Linke, Lisa Higuchi, W Seth Dukes

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