Amniocentesis before cerclage in asymptomatic women with mid-trimester short cervix: time to consider?

The authors investigate whether performing amniocentesis to analyze amniotic fluid for inflammatory markers and pathogens could improve the selection of asymptomatic women with mid-trimester short cervix who may benefit from cervical cerclage (CC). They highlight the potential for differentiating between mechanical and inflammatory cervical insufficiency, which could enhance the efficacy of treatment strategies and prevent preterm birth. The review aims to explore the role of intra-amniotic inflammation/infection in this context and advocate for a more individualized approach to maternal-fetal care.