Smooth Muscle Cell-Specific Expression of Cyclic Nucleotide Phosphodiesterase 10a Promotes the Development of Medial Artery Calcification

The authors aimed to investigate the role of phosphodiesterase 10A (PDE10A) in the development of medial artery calcification, particularly in the context of chronic kidney disease (CKD) and peripheral artery disease. They found that PDE10A expression was elevated in calcifying vascular smooth muscle cells and that its inhibition reduced calcification both in vitro and in vivo, suggesting that PDE10A is a critical mediator of this process and a potential therapeutic target.