Sex Dimorphism of NAD+De Novo Biosynthesis Mediates Sex-Biased Susceptibility to Ischemia-Reperfusion-Induced Acute Kidney Injury
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The authors investigate how sex differences influence susceptibility to ischemia-reperfusion-induced acute kidney injury (AKI) through the modulation of NAD+ de novo biosynthesis. They find that male mice are more vulnerable to AKI due to lower levels of NAD+ and impaired biosynthesis linked to downregulation of the enzyme kynureninase (KYNU), which is influenced by androgen levels. Their results suggest that targeting NAD+ metabolism could be a potential therapeutic strategy for mitigating sex-biased AKI.
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