June 16, 2026 · Journal of the American Society of Nephrology : JASN · DOI: 10.1681/ASN.0000001133

Elevations in Donor-Derived Cell-Free DNA and Allograft Outcomes in Kidney Transplantation

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The authors aimed to determine whether initial elevations in donor-derived cell-free DNA (dd-cfDNA) during routine surveillance could predict allograft dysfunction and loss in kidney transplant recipients. Their findings revealed that intermediate and high dd-cfDNA levels were associated with significantly increased risks of allograft loss, while persistently low levels correlated with favorable outcomes, indicating the potential of dd-cfDNA as a biomarker for monitoring transplant health.

Jeffrey A Klein, David Taber, David Wojciechowski, Didier A Mandelbrot, Renata Glehn-Ponsirenas, Oyedolamu Olaitan, Pranjal Jain, James Lu, Martina M McGrath, Mohanram Narayanan, Anup M Patel, Massini Merzkani, Nitipong Permpalung, Rashikh A Choudhury, Michelle A Josephson, Sanjiv Anand, Pradeep Vaitla, Eric Langewisch, Maria Ajaimy, Dhiren Kumar, George W Burke, Todd E Pesavento, Anthony J Langone, Yihung Huang, David Leeser, Bernard Fischbach, Nadiesda Costa, Kalathil Sureshkumar, Abd A Qannus, Chun-Po Steve Fan, Ziad Zaky, Fuad Shihab, Sanjay Kulkarni, Thin Thin Maw, Bekir Tanriover, Enver Akalin, Matthew Cooper, Ibrahim Tawhari, Matthew R Weir, Tarek Alhamad, Daniel C Brennan, Nicolae Leca, Suphamai Bunnapradist, Ling Shen, Robert N Woodward, Peale Chuang, Prince Anand, Emilio D Poggio, Giselle Guerra, Alexander Wiseman, Anil Paramesh, Diane Cibrik, Jonathan Bromberg, KOAR Study Investigators

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