Genetic Landscape of Kidney Failure in a Korean Transplant Cohort: Genome-Wide Association and Multi-Polygenic Risk Score Analyses
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The authors aimed to identify genetic loci associated with kidney failure and its subtypes, as well as evaluate the effectiveness of multi-polygenic risk scores (PRSs) in predicting kidney failure risk. Their genome-wide association study revealed distinct genetic factors linked to different subtypes of kidney failure, highlighting the disease's genetic heterogeneity. Additionally, the study demonstrated that multi-PRS models significantly enhance risk prediction compared to traditional clinical factors.
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