June 15, 2026 · Clinical radiology · DOI: 10.1016/j.crad.2026.107386

ADC histogram analysis for differentiating high-grade and low-grade meningiomas: a systematic review and meta-analysis

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The authors aimed to evaluate the effectiveness of ADC histogram analysis in preoperatively grading meningiomas, as accurate grading is crucial for treatment and prognosis. Their systematic review and meta-analysis of six studies involving 533 patients found that ADC histogram analysis demonstrated a pooled sensitivity of 71% and specificity of 72%, indicating its potential to enhance surgical decision-making and personalized patient management. They suggest that further research is needed for standardization and multicenter validation of this approach.

R T Fernandes, P E O Fonseca, L B Santos, B F Bonatti, A Dutra-Melo

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