Delayed 18F-FDG PET for the evaluation of suspected recurrent disease in brain metastases treated with radiation
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The authors aimed to evaluate the diagnostic utility of dual-timepoint 18F-FDG PET imaging in distinguishing progressive disease (PD) from radiation necrosis (RN) in patients with brain metastases showing suspicious MRI findings. Their findings indicate that the delayed T/B SUVmax ratios from PET imaging significantly differentiate PD from RN, potentially reducing false-positive diagnoses in equivocal MRI cases. However, they emphasize the need for prospective validation and standardized protocols to confirm these results.
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