Expression of Apolipoprotein L1 Risk Variants at the Plasma Membrane and Haplotype-Dependent Cytotoxicity
Listen to this summary
The authors aimed to elucidate the mechanisms by which apolipoprotein L1 (APOL1) risk variants G1 and G2 contribute to kidney disease in individuals of African ancestry. Their findings reveal that these variants facilitate increased calcium influx through the plasma membrane, leading to cytotoxicity, while the protective effects of the M1 variant and the APOL1 inhibitor VX-147 suggest potential therapeutic strategies to mitigate this risk.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Journal of the American Society of Nephrology : JASN
View all →Jun 23, 2026 · Journal of the American Society of Nephrology : JASN
Parathyroid Hormone Receptor 1 Facilitates Cyst Growth in Genetic Models of Autosomal Dominant Polycystic Kidney Disease
Jun 22, 2026 · Journal of the American Society of Nephrology : JASN
Alanyl-tRNA Synthetase 1 and Cyst Growth in Autosomal Dominant Polycystic Kidney Disease
Jun 20, 2026 · Journal of the American Society of Nephrology : JASN
Evaluating Barriers to Kidney Transplantation in the United States
Jun 19, 2026 · Journal of the American Society of Nephrology : JASN
Comparing Catheters to Fistulas in Older Patients Starting Hemodialysis (ACCESS HD)
Jun 17, 2026 · Journal of the American Society of Nephrology : JASN
Sex Dimorphism of NAD+De Novo Biosynthesis Mediates Sex-Biased Susceptibility to Ischemia-Reperfusion-Induced Acute Kidney Injury
Jun 17, 2026 · Journal of the American Society of Nephrology : JASN
Smooth Muscle Cell-Specific Expression of Cyclic Nucleotide Phosphodiesterase 10a Promotes the Development of Medial Artery Calcification
More in Pediatrics
View all →Jun 25, 2026 · Blood
Combining Quizartinib with intensive chemotherapy in older patients with newly diagnosed AML: results of the UK NCRI AML18 Trial
Jun 25, 2026 · Blood
Translational Regulation of Sf1 Integrates Alternative Splicing and Hematopoietic Stem Cell Fate
Jun 25, 2026 · Blood
Galectin-1 Fuels Monocyte Hyperinflammation and Represents a Novel Therapeutic Target in Myeloproliferative Neoplasms
Jun 25, 2026 · The American journal of sports medicine
Association of Central Acetabular Osteophytes With Microinstability and Increased Combined Anteversion in Borderline Dysplasia Hips
Jun 25, 2026 · Blood
NG2-ITGA4 axis regulates Rho GTPases and leukemic aggressiveness in KMT2A-r B-ALL and is targetable with natalizumab
Jun 24, 2026 · Critical care medicine
Ethical Implications of the Slow Code: A Systematic Review of Ethics of Slow Codes in U.S. Hospitals
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
