The Utility of Salivary 11-Dehydrodexamethasone as a Marker of Dexamethasone Absorption
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The authors investigate whether salivary 11-dehydrodexamethasone (11-DHD) can serve as a reliable marker for dexamethasone (DXM) absorption in patients undergoing the overnight dexamethasone suppression test (ONDST). Their findings reveal a strong positive correlation between serum DXM levels and salivary 11-DHD, suggesting that measuring 11-DHD could enhance the diagnostic process by allowing for convenient at-home sample collection. This novel approach may improve patient pathways in the assessment of hypercortisolism.
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