The Journal of clinical endocrinology and metabolism
Audio Summaries

Approach to the Patient: Cases of Hormonal Management in Older Transgender and Gender Diverse Adults

Jun 11, 2026

This article addresses the management of gender-affirming hormone therapy (GAHT) in older transgender and gender diverse (TGD) adults, particularly in the context of age-related health issues such as neurocognitive disorders, cardiovascular disease, prostate cancer, bone health, and menopause. The authors aim to provide a case-based framework for healthcare providers, highlighting the lack of specific evidence-based guidelines for this population and the need for future research to establish best practices.

Cardiovascular effects of metyrapone treatment in patients with mild autonomous cortisol secretion: a secondary analysis

Jun 11, 2026

This study investigates the cardiovascular effects of metyrapone treatment in patients with mild autonomous cortisol secretion (MACS), specifically examining its impact on blood pressure, cardiac fat depots, and other cardiovascular risk factors. The results indicate that metyrapone treatment significantly reduced both systolic and diastolic blood pressure and decreased epicardial fat, while no changes were observed in cardiac function or morphology. Overall, the findings suggest that cortisol-lowering therapy may improve cardiovascular health in patients with MACS.

The Utility of Salivary 11-Dehydrodexamethasone as a Marker of Dexamethasone Absorption

Jun 11, 2026

The authors investigate whether salivary 11-dehydrodexamethasone (11-DHD) can serve as a reliable marker for dexamethasone (DXM) absorption in patients undergoing the overnight dexamethasone suppression test (ONDST). Their findings reveal a strong positive correlation between serum DXM levels and salivary 11-DHD, suggesting that measuring 11-DHD could enhance the diagnostic process by allowing for convenient at-home sample collection. This novel approach may improve patient pathways in the assessment of hypercortisolism.