Use of Predicted Risk and Expected Benefit to Guide Decision-Making in Cardiovascular-Kidney-Metabolic Syndrome for the Primary Prevention of Cardiovascular Disease: A Scientific Statement From the American Heart Association and American College of Cardiology

The authors aim to establish a comprehensive framework for the primary prevention of cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome by integrating predicted risk assessments with expected treatment benefits. They advocate for the use of the PREVENT equations to guide clinical decision-making regarding the initiation and intensification of therapies, emphasizing the importance of shared decision-making and effective risk communication. This scientific statement outlines the rationale, evidence, and practical guidance for implementing these recommendations to improve patient outcomes.