Depicting the Immunological Landscape of Basal Cell Carcinoma Subtypes

The authors aimed to characterize the immunological landscape of different basal cell carcinoma (BCC) subtypes by examining PD-L1, dendritic cells, and HLA expression through immunohistochemistry. Their findings revealed that while PD-L1 was not expressed on BCC tumor cells, it was present on immune cells, particularly in basosquamous BCCs, suggesting that this subtype may be more responsive to anti-PD-1 therapy than others. Overall, the study highlights the immune-privileged status of BCC and challenges existing notions regarding PD-L1 expression in these tumors.