Journal of cutaneous pathology
Audio Summaries

TFG-Containing Fusions in Melanocytic Tumors: From Polymorphic Read-Through Transcripts to Oncogenic Kinase Fusions

Jun 9, 2026

The authors investigate the presence and significance of TFG gene fusions in melanocytic tumors, identifying that 8.6% of a studied cohort harbored such fusions. They specifically characterize a TFG::NTRK3 fusion as indicative of a Spitz pathway and suggest that the TFG::ADGRG7 fusion may represent a benign polymorphic variant rather than a pathogenic driver. The study emphasizes the importance of accurately reporting and interpreting these molecular findings to enhance diagnosis and treatment strategies in melanocytic tumors.

Depicting the Immunological Landscape of Basal Cell Carcinoma Subtypes

Jun 9, 2026

The authors aimed to characterize the immunological landscape of different basal cell carcinoma (BCC) subtypes by examining PD-L1, dendritic cells, and HLA expression through immunohistochemistry. Their findings revealed that while PD-L1 was not expressed on BCC tumor cells, it was present on immune cells, particularly in basosquamous BCCs, suggesting that this subtype may be more responsive to anti-PD-1 therapy than others. Overall, the study highlights the immune-privileged status of BCC and challenges existing notions regarding PD-L1 expression in these tumors.

Dermatofibroma Hypocellularity Is Associated With Patient Age: A Retrospective Study of 307 Cases

Jun 7, 2026

This study investigates the relationship between patient age and the prevalence of hypocellular dermatofibromas, a variant of benign fibrohistiocytic neoplasms. The authors found a significant positive correlation, indicating that the frequency of hypocellular dermatofibromas increases with age, suggesting that these lesions may undergo gradual involution and reduced cellular density over time.