TFG-Containing Fusions in Melanocytic Tumors: From Polymorphic Read-Through Transcripts to Oncogenic Kinase Fusions

The authors investigate the presence and significance of TFG gene fusions in melanocytic tumors, identifying that 8.6% of a studied cohort harbored such fusions. They specifically characterize a TFG::NTRK3 fusion as indicative of a Spitz pathway and suggest that the TFG::ADGRG7 fusion may represent a benign polymorphic variant rather than a pathogenic driver. The study emphasizes the importance of accurately reporting and interpreting these molecular findings to enhance diagnosis and treatment strategies in melanocytic tumors.