June 11, 2026 · Gut · DOI: 10.1136/gutjnl-2026-338801

Microbiota and metabolites modulation of cancer stem cells and chemotherapy sensitivity

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This review explores how the microbiota and its metabolites influence cancer stem cells (CSCs) and their role in chemotherapy resistance. The authors aim to elucidate the mechanisms by which commensal microbes and their metabolites affect CSC function and the tumor microenvironment, while also discussing potential therapeutic strategies to target these interactions to enhance chemosensitivity and improve patient outcomes.

Feifei Fang, Harry Cheuk-Hay Lau, Jun Yu

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