Dual mechanism of immune escape shapes the genetic and immunogenic landscape of mismatch repair-deficient colorectal tumours
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The authors aim to understand how host immunity influences the genomic architecture and tumor microenvironment of mismatch repair-deficient (MMRd) colorectal cancers. Their findings reveal a dual mechanism of immune escape—immunoediting and local immunosuppression—that allows MMRd tumors to persist despite being immunogenic, highlighting potential therapeutic vulnerabilities for neoantigen-based or immune reactivation strategies.
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