Colonoscopy versus biennial FIT screening: a post hoc sustained-strategy analysis of the COLONPREV Trial
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The authors aimed to compare the 10-year risks of colorectal cancer (CRC) mortality, incidence, and all-cause mortality between one-time colonoscopy and sustained biennial fecal immunochemical testing (FIT) in the COLONPREV Trial. Their analysis revealed similar risks for CRC incidence and all-cause mortality between the two screening strategies, while colonoscopy showed a lower but imprecise estimate for CRC mortality. The findings underscore the significance of adherence in interpreting outcomes from pragmatic screening trials.
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