A subphenotype of obesity with reduced enteroendocrine GLP-1 synthesis and enhanced tirzepatide response
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The authors aimed to investigate the pathophysiological mechanisms underlying a specific subphenotype of obesity characterized by fast gastric emptying and low postprandial GLP-1 levels, and to evaluate its response to the GLP-1-based therapy tirzepatide. They identified a cluster of individuals with this phenotype who exhibited reduced mucosal hormone synthesis and demonstrated greater weight loss with tirzepatide compared to other obesity subphenotypes. The study highlights the need for further research to understand the mechanisms contributing to GLP-1 deficiency in this group.
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