June 5, 2026 · European heart journal · DOI: 10.1093/eurheartj/ehag400

Predicting lifetime cardiovascular risk and benefits of preventive treatment in patients with established atherosclerotic cardiovascular disease: the SMART-REACH2 model

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The authors aimed to develop the SMART-REACH2 model to estimate the lifetime risk of recurrent cardiovascular (CV) events and the benefits of preventive treatment in patients with established atherosclerotic CV disease, incorporating geographical and sex-specific variations. The model was validated in a large cohort and demonstrated adequate performance across different risk regions, providing insights into potential gains in CV disease-free life expectancy with intensified treatment. This tool aims to enhance shared decision-making in clinical practice as recommended by current guidelines.

Joris Holtrop, Mari N Gynnild, Salil V Deo, Carl-Emil Lim, Stelios Boulitsakis Logothetis, Kristi Läll, Minna Oksanen, Håvard Dalen, John Munkhaugen, Peter Ueda, Tomas Jernberg, José Tuñón, Ignacio Mahíllo Fernández, Ingvild Saltvedt, Hanne Ellekjær, Martin Teraa, Manon G van der Meer, Ynte M Ruigrok, Urmo Võsa, Małgorzata Chlabicz, Karol Kaminski, Ph Gabriel Steg, Ivana Burazor, Reedik Mägi, Taavi Tillmann, David A Wood, Kausik K Ray, Dirk de Bacquer, Janne Martikainen, John William McEvoy, Stephen Kaptoge, Frank L J Visseren, Emanuele Di Angelantonio, Deepak L Bhatt, Angela Wood, Steven H J Hageman, Jannick A N Dorresteijn

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