ACADM-mediated fatty acid β-oxidation pathway in atherosclerosis and abdominal aortic aneurysm

This study investigates the distinct roles of lipid metabolic disturbances in the pathogenesis of atherosclerosis (AS) and abdominal aortic aneurysm (AAA). Through lipidomic analysis and multi-omics approaches, the authors identify significant differences in lipid profiles between the two conditions, particularly highlighting the Acadm-mediated fatty acid β-oxidation pathway as a key factor in AS but not in AAA. The findings suggest potential avenues for differential diagnosis and targeted treatments based on these lipid metabolic characteristics.