May 22, 2026 · The American journal of medicine · DOI: 10.1016/j.amjmed.2026.05.024

Cost-Effectiveness of Recombinant Zoster Vaccine (Shingrix) in U.S. Adults Aged ≥50 Years

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The authors aimed to evaluate the cost-effectiveness of the recombinant zoster vaccine (Shingrix) in U.S. adults aged 50 years and older, considering new evidence on its long-term efficacy and pricing. Their analysis revealed that the vaccine is cost-effective for individuals aged 60 and older, with an optimal vaccination age identified around 54 years. The study underscores the importance of ongoing assessments of the vaccine's long-term protection and the potential need for booster doses.

Yihua Yue, Phuc Le, Olajide Adekunle, Ha T Tran, Michael B Rothberg

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