June 23, 2026 · The American journal of medicine · DOI: 10.1016/j.amjmed.2026.06.006

Assessment of in-hospital mortality in patients with upper gastrointestinal bleeding on antithrombotic treatment: A Systematic Review and Meta-Analysis

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This systematic review and meta-analysis aimed to determine the impact of antithrombotic therapy on in-hospital mortality in patients with upper gastrointestinal bleeding. The findings indicated that antithrombotic therapy at admission was not associated with increased in-hospital mortality and suggested a protective trend, particularly for antiplatelet agents and in cases of non-variceal bleeding. The authors emphasize that these results should be interpreted as a prognostic association rather than definitive causation.

Raúl Fernández-García, Raúl Mendoza-Rodríguez, Francisco Valverde-López, Rita Jiménez-Rosales, María Del Carmen Olvera-Porcel, Eduardo Redondo-Cerezo

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