May 12, 2026 · Journal of addictive diseases · DOI: 10.1080/10550887.2026.2653228

Association of GLP-1 receptor agonist use with long-term outcomes in patients with opioid use disorder

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The authors aimed to investigate the long-term outcomes associated with the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in patients with opioid use disorder (OUD). Their retrospective cohort study found that GLP-1RA use was linked to significantly lower all-cause mortality, reduced overdose risk, and decreased healthcare utilization compared to non-users, suggesting potential benefits of GLP-1RAs as adjunctive therapies for OUD.

Dhairya A Lakhani, Wanhong Zheng

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