Natural cycle frozen embryo transfer reduces obstetric complications: an inverse probability of treatment-weighted analysis
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The authors aimed to compare obstetric complications between hormone replacement treatment (HRT) and natural cycle (NC) frozen embryo transfer (FET) and assess the impact of a policy shift towards NC on clinical outcomes. Their analysis revealed that NC is associated with lower miscarriage rates and fewer major obstetric complications compared to HRT, and that increasing the proportion of NC in treatment protocols correlates with significant reductions in adverse outcomes. This supports a transition towards prioritizing NC in clinical practice.
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