Non-invasive prenatal testing as a prenatal screening test in pregnancies following assisted reproductive technologies: a diagnostic test accuracy systematic review and meta-analysis

The authors aimed to evaluate the diagnostic accuracy of non-invasive prenatal testing (NIPT) for detecting common chromosomal abnormalities in pregnancies resulting from assisted reproductive technologies (ART). Their systematic review and meta-analysis found that while NIPT exhibits high specificity (99.6% for singletons and 99.8% for twins), its sensitivity (88.2% for both singleton and twin ART pregnancies) is notably lower compared to naturally-conceived pregnancies, particularly for trisomy 21. This highlights the need for cautious interpretation of NIPT results in ART pregnancies.