April 22, 2026 · Journal of addictive diseases · DOI: 10.1080/10550887.2026.2656693

Cytotoxic lesion of the corpus callosum after gamma hydroxybutyrate withdrawal: a case report

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This case report investigates the neuroimaging correlates of neurotoxicity associated with withdrawal from gamma-hydroxybutyrate (GHB), particularly focusing on the occurrence of cytotoxic lesions in the corpus callosum. The authors present a case of a 33-year-old male who experienced severe withdrawal symptoms and a focal splenial lesion, suggesting that such lesions may serve as significant indicators of GHB withdrawal-related neurotoxicity. The findings highlight the need for further research into the neurological effects of GHB withdrawal.

Kuang Heng Wang, Kuei Hong Kuo, Hsien Hsueh Shih, Yi Ju Pan

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