April 19, 2026 · Resuscitation · DOI: 10.1016/j.resuscitation.2026.111101

EEG-guided early cessation of sedation and TTM in patients after cardiac arrest: a feasibility and safety study

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The authors aimed to investigate the feasibility and safety of early cessation of sedation and targeted temperature management (TTM) in comatose patients after cardiac arrest who exhibit a favorable EEG pattern within 12 hours. Their study found that early withdrawal of sedation and TTM significantly reduced the duration of mechanical ventilation and ICU length of stay without increasing complications, although it was underpowered to assess long-term neurological outcomes. The findings suggest that tailored approaches based on EEG patterns may enhance patient care, warranting further research.

Marleen C Tjepkema-Cloostermans, Albertus Beishuizen, Aart C Strang, Hanneke M Keijzer, Johan A Telleman, Simone P Smook, J Wytze Vermeijden, Jeannette Hofmeijer, Michel J A M van Putten

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