Rhythm-specific association of epinephrine with outcomes in non-shockable cardiac arrest: A nationwide propensity-matched study
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This study aimed to determine how the association between epinephrine administration and return of spontaneous circulation (ROSC) differs between patients with asystole and those with pulseless electrical activity (PEA) during out-of-hospital cardiac arrest. The findings revealed that epinephrine was more strongly associated with ROSC in asystole patients compared to those with PEA shortly after emergency medical service contact, although this difference diminished over time. Additionally, while a similar trend was observed for 30-day survival rates, no significant differences were noted in favorable neurological outcomes between the two groups.
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