Efficacy and safety of VPM1002 and Immuvac in preventing tuberculosis: phase 3 randomised clinical trial (PreVenTB trial)
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The PreVenTB trial aimed to evaluate the safety and efficacy of the vaccines VPM1002 and Immuvac in preventing microbiologically confirmed tuberculosis (TB) among healthy household contacts of TB patients. The results indicated that while both vaccines were well tolerated, VPM1002 demonstrated significant efficacy against extrapulmonary TB, particularly in participants with a positive tuberculin skin test, but neither vaccine showed efficacy against all forms of confirmed TB or pulmonary TB. Overall, the study highlights the potential of VPM1002 in specific populations, despite limited effectiveness in broader TB prevention.
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