Advances in the drug treatment of Alzheimer's disease: pathophysiology and mechanisms of action
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The authors review recent advances in the drug treatment of Alzheimer's disease, aiming to address the multifactorial nature of the disorder, including amyloid beta and tau pathology, neuroinflammation, and metabolic dysfunction. They highlight the need for combination therapies that target these diverse mechanisms to improve patient outcomes, as current anti-Aβ treatments do not fully prevent cognitive decline. The paper discusses emerging multimodal strategies in late-stage development that could enhance treatment efficacy and quality of life for patients.
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