March 23, 2026 · JAMA · DOI: 10.1001/jama.2026.1221

Diagnosis and Management of Resistant Hypertension: A Review

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The authors aim to address the diagnosis and management of resistant hypertension, which affects approximately 10% of patients despite treatment. They highlight the importance of excluding factors such as white-coat hypertension and medication nonadherence, and recommend lifestyle modifications, optimized pharmacologic therapy, and interventions like spironolactone and renal denervation to effectively lower blood pressure in these patients.

Michel Azizi, Wanpen Vongpatanasin, Naomi D L Fisher, Felix Mahfoud, Laurence Amar, Ajay J Kirtane

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