Molecularly guided therapies for advanced primary liver cancers refractory to systemic treatment: Results from the 2025 French Genomic Medicine Initiative
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The authors aimed to evaluate the feasibility and clinical impact of comprehensive genomic profiling in patients with advanced primary liver cancers (PLC) who are refractory to systemic treatments. They found that nearly two-thirds of the patients had actionable genomic alterations, leading to disease control in a subset of those treated with matched therapies. This study underscores the potential of genomics-guided strategies to enhance personalized treatment options and improve outcomes for patients with hepatobiliary malignancies.
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