Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis
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The authors aimed to investigate the cellular and molecular mechanisms underlying autoimmune hepatitis (AIH) and to validate a potential therapeutic target through a clinical trial. Their findings identified TNF as a central node in the immune network driving T cell-mediated cytotoxicity in AIH, and the phase IIa trial demonstrated the efficacy of infliximab, a TNF-targeting antibody, as a steroid-free treatment option. This research highlights the potential for targeted therapies in AIH, paving the way for safer and more specific treatment strategies.
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