Tissue-specific regulation of PNPLA3 promotes lipid remodeling in response to dietary and environmental challenges: Tissue-specific PNPLA3 lipid remodeling
Listen to this summary
The authors investigate the tissue-specific regulation of PNPLA3 and its role in lipid remodeling, particularly in the context of steatotic liver disease (SLD). They find that PNPLA3 expression is significantly influenced by dietary and environmental factors, with distinct regulatory mechanisms in liver and brown adipose tissue. Their results suggest that PNPLA3 modulates lipid composition in response to metabolic stress, highlighting its potential as a therapeutic target for SLD.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Journal of hepatology
View all →Mar 22, 2026 · Journal of hepatology
Molecularly guided therapies for advanced primary liver cancers refractory to systemic treatment: Results from the 2025 French Genomic Medicine Initiative
Mar 22, 2026 · Journal of hepatology
Ammonia measurement in cirrhosis: International Delphi consensus recommendations from ISHEN
Mar 21, 2026 · Journal of hepatology
Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis
Mar 20, 2026 · Journal of hepatology
IFRD1 orchestrates hepatocyte metabolism and macrophage interactions to facilitate liver regeneration
Mar 19, 2026 · Journal of hepatology
Characterization of ferroportin disease and SLC40A1-related hemochromatosis - Results from the EASL non-HFE registry
Mar 13, 2026 · Journal of hepatology
An immunocompetent murine model of virus-elicited liver fibrosis and hepatocellular carcinoma
More in Internal Medicine
View all →Mar 25, 2026 · Gastroenterology
From Autoimmunity to Intestinal Tissue Damage: Insights From Potential Celiac Disease as a Paradigm of Disease Progression
Mar 25, 2026 · The American journal of sports medicine
Deltoid Osteomuscular Transfer Suppresses Humeral Head Translation Caused by Massive Irreparable Rotator Cuff Tears: A Cadaveric Biomechanical Study
Mar 25, 2026 · The American journal of medicine
Antiphospholipid Antibodies among Hospitalized Patients Predict Mortality and Readmission: A Real-World 10-Years Cohort Study
Mar 25, 2026 · British journal of sports medicine
Injury risk and its relationship with biological maturation among 100 junior tennis athletes: a 15-year retrospective analysis
Mar 25, 2026 · The American journal of medicine
Evaluation of Patients Presenting to a Multidisciplinary Lymphatic Center
Mar 25, 2026 · The American journal of medicine
Pathophysiology, Diagnosis, and Management of Cervical Disc Herniation
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
