An immunocompetent murine model of virus-elicited liver fibrosis and hepatocellular carcinoma
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The authors aim to develop a small animal model that accurately reflects the progression from chronic viral hepatitis to hepatocellular carcinoma (HCC) to facilitate mechanistic studies and therapeutic development. They demonstrate that chronic infection with Norway rat hepacivirus (NrHV) in immunocompetent mice induces liver fibrosis and HCC, mirroring the characteristics of hepatitis C virus (HCV)-associated tumors. This model provides a valuable platform for investigating virus-host interactions and testing potential treatments for liver cancer.
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