Distinct molecular pathways regulated by activated AKT and YAP signaling during intrahepatic cholangiocarcinoma progression: Roles of AKT and YAP during iCCA

The authors investigate the distinct roles of activated AKT and YAP signaling in the progression of intrahepatic cholangiocarcinoma (iCCA) and their effects on the tumor microenvironment. Using doxycycline-inducible mouse models, they demonstrate that while both pathways regulate tumor cell proliferation, AKT primarily influences metabolic pathways and YAP modulates differentiation and immune suppression. Their findings suggest that combining YAP inhibition with immune checkpoint inhibitors could enhance therapeutic outcomes in iCCA treatment.