Kupffer cell plasticity regulates hepatic immunity in mycobacterial infection: Kupffer cell plasticity

The authors investigate the plasticity of Kupffer cells (KCs) in the context of chronic mycobacterial infections, aiming to understand their role and adaptations during such infections. They reveal that KCs can exhibit significant plasticity, giving rise to a unique subset (KC^low) that plays a crucial role in the antimycobacterial response, while also highlighting the importance of monocyte-derived macrophages in granuloma formation. This study challenges the traditional view of KCs as terminally differentiated cells, demonstrating their ability to adapt to extreme environmental changes during infection.