March 16, 2026 · BJOG : an international journal of obstetrics and gynaecology · DOI: 10.1111/1471-0528.70213

Comparative Efficacy of Elinzanetant Versus Other Non-Hormonal Pharmaceutical Therapies for the Treatment of Moderate-to-Severe Vasomotor Symptoms Associated With Menopause: A Network Meta-Analysis

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The authors aimed to compare the efficacy of elinzanetant, a novel non-hormonal therapy, with other non-hormonal pharmaceutical treatments for alleviating moderate-to-severe vasomotor symptoms (VMS) associated with menopause. The network meta-analysis of 17 randomized controlled trials revealed that elinzanetant significantly reduced VMS frequency and severity compared to several other treatments, while also improving sleep disturbances, thereby supporting its effectiveness in managing VMS.

Piotr Wojciechowski, Klaudia Kolonko, Andromachi Giannopoulou, Beata Smela, Elżbieta Olewinska, Kristina Rosa Bolling, Jenifer Sassarini, Lee P Shulman, Vikram Talaulikar

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