March 16, 2026 · BJOG : an international journal of obstetrics and gynaecology · DOI: 10.1111/1471-0528.70221

Prenatal Prescription Opioid Analgesic Exposure and Academic Performance in Third Grade Children: A Population-Based Cohort Study

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The authors aimed to investigate the relationship between prenatal exposure to opioid analgesics and academic performance in third-grade children. Their population-based cohort study found that while exposure to codeine and oxycodone did not significantly affect standardized reading and numeracy scores, tramadol exposure was associated with lower scores, suggesting a need for further research to clarify these findings and potential confounding factors.

Bianca Varney, Helga Zoega, Malcolm B Gillies, Claudia Bruno, Alys Havard, Antonia Shand, Natasha Nassar, Jonathan Brett

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