3-Dimensional quantification of ischemic brain injury in post-cardiac arrest patients with hypoxic-ischemic brain injury

The authors aimed to develop a reproducible, semi-automated analysis pipeline to quantitatively assess and anatomically localize ischemic brain injury in post-cardiac arrest patients with hypoxic-ischemic brain injury (HIBI) using diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) maps. Their findings revealed that ischemic injury was heterogeneous, predominantly affecting specific brain regions, with a significant lesion burden in white matter compared to gray matter. This study provides a robust method for detailed quantification of ischemic injury, enhancing the understanding of HIBI following cardiac arrest.