POST-CARDIAC ARREST BRAIN INJURY MODEL: NEUROBIOMARKER KINETICS FOLLOWING GLOBAL CEREBRAL HYPOPERFUSION-REPERFUSION

The authors aimed to characterize the kinetics of blood-based neurobiomarkers following brief episodes of global cerebral hypoperfusion and reperfusion induced by rapid ventricular pacing during transcatheter aortic valve implantation (TAVI). They found that while neuron specific enolase (NSE) levels increased progressively over time, S100B exhibited an inverse U-shaped profile, indicating distinct responses to ischemia and reperfusion, despite no patients developing neurological deficits. This study highlights the potential for measurable neurobiomarker changes during controlled low-flow states that may not manifest as clinical symptoms.