March 19, 2026 · Resuscitation · DOI: 10.1016/j.resuscitation.2026.111062

Impact of tidal volume during cardiopulmonary resuscitation: an experimental pilot porcine study

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This study investigates the impact of different tidal volumes (V<sub>T</sub>) during cardiopulmonary resuscitation (CPR) on hemodynamics and whether capnogram analysis can assess ventilation's influence on circulation. The results indicate that a V<sub>T</sub> of 10 ml/kg optimizes cerebral and coronary perfusion pressures compared to lower or higher volumes, while capnogram analysis effectively distinguishes thoracic distension levels associated with hemodynamic changes. The findings suggest a U-shaped relationship between V<sub>T</sub> and circulation, highlighting the potential for capnogram monitoring in optimizing CPR ventilation settings.

Arnaud Lesimple, Jean-Christophe Richard, Fanny Lidouren, Naoto Watanabe, Laura Polard, Lilith Faucheux, Patrick Bruneval, Hugo Schmit, Ricardo Cordioli, Alain Mercat, Laurent Brochard, Alice Hutin, Renaud Tissier

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